Jennifer Syme

On April 1, 2001, Syme attended a party at musician Marilyn Manson's home. After being driven home by another party guest shortly before dawn, she left her home, reportedly to return to the party. On the morning of April 2, Syme drove her 1999 Jeep Grand Cherokee into a row of parked cars on Cahuenga Boulevard in Los Angeles. She was partially ejected from the vehicle and died instantly. Syme was 28 years old. Syme is buried next to her daughter in Westwood Village Memorial Park Cemetery in Los Angeles.

In tribute to Syme's memory, David Lynch dedicated the 2001 film Mulholland Drive to her. In April 2002, Syme's mother, Maria St. John, sued Marilyn Manson for wrongful death for giving Syme "various quantities of an illegal controlled substance" and for "instructing [Syme] to operate a motor vehicle in her incapacitated condition". Shortly after the lawsuit was filed, Manson issued a statement denying responsibility for Syme's death, stating that the lawsuit was "completely without merit".

On December 24, 1999, she gave birth eight months into her pregnancy to Ava Archer Syme-Reeves, her child with actor Keanu Reeves. The child was stillborn. The strain put on their relationship by their grief resulted in their breakup several weeks later.

Jennifer Maria Syme (December 7, 1972 – April 2, 2001) was an American actress and personal assistant. She was in a relationship with fellow actor Keanu Reeves from 1998 until their break-up in 2000, several weeks after the death of their daughter due to stillbirth.