Börje Haraldsson

In 2015, Haraldsson resigned his clinical professorship to join Novartis in Switzerland. As he returned to Sweden in 2022, he rejoined the University of Gothenburg as Professor of Physiology.

In 2014, Haraldsson held appointment as an Executive Director at Novartis Institute of Biomedical research (NIBR). After working there as a translational medicine expert in the ATI department for 3 years, he became Global Program Head in immunology, hepatology and dermatology (IHD) in 2018. In 2022, he left Novartis to become CSO, and four months later CEO, at Oncorena AB.

Building on work by William Deen, Haraldsson developed the first unified heterogenous charged fiber model, while incorporating the effects of solute size and charge. He along with co-workers, also demonstrated how the structure of the ESL can be affected by enzymes, ischemia-reperfusion injury, or ionic strength, causing proteinuria. He studied the interaction between podocytes, the endothelial cells, and their ESL, and presented conditions with disturbed communication causing proteinuria. In 2014, together with colleagues in New York, he confirmed the reciprocal crosstalk between podocytes and endothelial cells in a coculture system, and further highlighted that segmental glomerulosclerosis develops as a result of podocyte-endothelial crosstalk mediated by EDN1/EDNRA-dependent mitochondrial dysfunction.

Haraldsson was appointed as an associate professor (docent) of Physiology at Gothenburg University till 2000, and as a Professor and Chair of Nephrology till 2015. During this time period, he also held concurrent appointments as Researcher in integrative physiology, as Department Head, as Director of the university board, and as Vice Dean for the Sahlgrenska academy at the University of Gothenburg. Moreover, he chaired several Swedish Research Council’s expert panels, and served as scientific secretary of the Gothenburg Medical Association. From 2011 till 2014, he was a visiting professor of medicine at Mount Sinai School of medicine in New York.

Haraldsson is also the one to discover the role of orosomucoid in terms of maintenance of normal capillary permselectivity. He regarded the endothelial cell surface layer (ESL) to be the key contributor in the context of the glomerular barrier. In a study conducted in 1993, he discussed the application of plasma glycoprotein orosomucoid in regulating the dynamic properties of the glomerular capillary wall by reducing the permeability towards macromolecules. He developed a computer model for individualized therapy of patients with PD, and regarded total pore area over diffusion distance (A(0)/Deltax) to be the significant parameter to describe exchange across the peritoneal membrane.

Haraldsson’s research group published a series of papers focused on the understanding of the glomerular barrier, its properties, and the role of its individual components. In a paper published in 1992, he highlighted the role of orosomucoid in terms of maintenance of normal capillary permeability in skeletal muscle and mesentery. The research group also demonstrated that serum proteins other than albumin and orosomucoid are less important for the maintenance of normal capillary permeability. In 2003, he and Jeansson conducted the first functional study of glomerular size and charge selectivity in mice to explore the controversial issue of glomerular permselectivity in animals exposed to glucosaminoglycan-degrading enzymes, hyaluronidase, and heparinase. It was found out that polysaccharide-rich structures, such as the endothelial cell coat are key components in the glomerular barrier.

During his doctoral studies, Haraldsson began his clinical career as a part-time physician in emergency rooms in Borås, Vänersborg, Bäckefors, and Lysekil. He completed his internship at Mölndals hospital, Sweden in 1989, and was subsequently appointed by Sahlgrenska university hospital as Resident Physician. Afterward, he served there as an attending physician till 2000, and as senior consultant till 2014.

Haraldsson was born on October 14, 1957, in Borås, Sweden. After completing his early education in a high school at Bäckängsgymnasiet, he started medical school at the University of Gothenburg in 1976. There he performed his graduate work in physiology to receive his M.D. in 1982 and Ph.D in 1986, under the supervision of Bengt Rippe and Björn Folkow. His dissertation was titled "Physiological studies of macromolecular transport across capillary walls".