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Bruce Beutler is an American immunologist and geneticist who was born on December 29, 1957 in Chicago, Illinois. He is the recipient of the 2011 Nobel Prize in Physiology or Medicine, which he shared with Jules Hoffmann and Ralph Steinman. Beutler received his B.A. in biology from the University of Chicago in 1979 and his M.D. from the University of Texas Southwestern Medical School in 1983. He then completed his residency in internal medicine at the University of California, San Diego in 1986. Beutler has made significant contributions to the field of immunology, particularly in the area of innate immunity. He has identified several key components of the innate immune system, including Toll-like receptors, which are involved in the recognition of pathogens. He has also identified several genes involved in the regulation of the immune system, including the NOD2 gene, which is associated with Crohn's disease. Beutler is currently the Director of the Center for the Genetics of Host Defense at the University of Texas Southwestern Medical Center. He is also a professor of pathology and immunology at the same institution. He is a member of the National Academy of Sciences and the Institute of Medicine.

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Age 66 years old
Zodiac Sign Capricorn
Born 29 December 1957
Birthday 29 December
Birthplace Chicago, Illinois
Nationality United States

We recommend you to check the complete list of Famous People born on 29 December. He is a member of famous with the age 66 years old group.

Bruce Beutler Height, Weight & Measurements

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Who Is Bruce Beutler's Wife?

His wife is Barbara Lanzl (c. 1980-1988; divorced; 3 children)

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Wife Barbara Lanzl (c. 1980-1988; divorced; 3 children)
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Bruce Beutler Net Worth

His net worth has been growing significantly in 2022-2023. So, how much is Bruce Beutler worth at the age of 66 years old? Bruce Beutler’s income source is mostly from being a successful . He is from United States. We have estimated Bruce Beutler's net worth , money, salary, income, and assets.

Net Worth in 2023 $1 Million - $5 Million
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Timeline

2011

On October 4, 2011, Beutler was named regental professor of the University of Texas System.

2000

In 2000, Beutler moved to The Scripps Research Institute in La Jolla, California, as a professor in the Department of Immunology. In 2007, he became chairman of the newly created Department of Genetics at Scripps Research. In 2011, Beutler returned to UT Southwestern Medical Center to become director of the Center for the Genetics of Host Defense.

1998

The positional cloning of Lps was completed in 1998. Beutler thereafter continued to apply a forward genetic approach to the analysis of immunity in mammals. In this process, germline mutations that alter immune function are created through a random process using the alkylating agent ENU, detected by their phenotypic effects, and then isolated by positional cloning. His work disclosed numerous essential signaling molecules required for the innate immune response, and helped to delineate the biochemistry of innate immunity.

1986

Beutler returned to Dallas in 1986 as an assistant professor in the Department of Internal Medicine of the University of Texas Southwestern Medical Center at Dallas, and an Assistant Investigator at the Howard Hughes Medical Institute, where he retained a position for the next 14 years. He became an associate professor and an associate investigator with HHMI in 1990, and a professor in 1996.

1980

Beutler is Ashkenazi Jewish, the son of Ernest Beutler (geneticist) and Brondelle May Fleisher (journalist). He married Barbara Beutler (née Lanzl) in 1980 and divorced in 1988, Beutler has three children: Daniel (born 1983), Elliot (born 1984), and Jonathan (born 1987).

1976

Beutler majored in biology as an undergraduate at the University of California, San Diego, where he graduated in 1976 at the age of 18. He attended medical school at the University of Chicago. From 1981 to 1983 Beutler continued his medical training at the University of Texas Southwestern Medical Center in Dallas, Texas, as an intern in the Department of Internal Medicine, and as a resident in the Department of Neurology. Between 1983 and 1985 he was a postdoctoral fellow at Rockefeller University in the laboratory of Anthony Cerami. He became an Assistant Professor at Rockefeller University in 1985. He was also an Associate Physician at the Rockefeller University Hospital between 1984 and 1986.

1960

Beutler is best known for his pioneering molecular and genetic studies of inflammation and innate immunity. He was the first to isolate mouse tumor necrosis factor-alpha (TNF), and to demonstrate the inflammatory potential of this cytokine, proving its important role in endotoxin-induced shock. Subsequently, he invented recombinant molecules expressly designed to neutralize TNF, fusing the binding portion of TNF receptor proteins to the heavy chain of an immunoglobulin molecule to force receptor dimerization. These molecules were later used extensively as the drug Etanercept in the treatment of rheumatoid arthritis, Crohn's disease, psoriasis, and other forms of inflammation. Interested in the mechanism by which LPS activates mammalian immune cells, Beutler used TNF production as a phenotypic endpoint to identify the LPS receptor. Identification of the receptor hinged on the positional cloning of the mammalian Lps locus, which had been known since the 1960s as a key genetic determinant of all biological responses to LPS. Beutler thus discovered the key sensors of microbial infection in mammals, demonstrating that one of the mammalian Toll-like receptors, TLR4, acts as the membrane-spanning component of the mammalian LPS receptor complex. The TLRs (of which ten are now known to exist in humans) are now widely known to function in the perception of microbes, each detecting signature molecules that herald infection. These receptors also mediate severe illness, including shock and systemic inflammation as it occurs in the course of an infection. They are central to the pathogenesis of sterile inflammatory and autoimmune diseases such as systemic lupus erythematosus. The research on TLRs won him the Nobel Prize in 2011.

1959

Between 1959 and 1977, Beutler lived in Southern California. He received his secondary school education at Polytechnic School in Pasadena, California. He attended college at the University of California, San Diego, graduating at the age of 18 in 1976. He enrolled in medical school at the University of Chicago in 1977 and received his M.D. degree in 1981 at the age of 23.

1957

Bruce Alan Beutler (born December 29, 1957) is an American immunologist and geneticist. Together with Jules A. Hoffmann, he received one-half of the 2011 Nobel Prize in Physiology or Medicine, for "their discoveries concerning the activation of innate immunity" (the other half went to Ralph M. Steinman for "his discovery of the dendritic cell and its role in adaptive immunity").