V. K. Sasikala

On 5 February 2017, Sasikala was unanimously elected as the AIADMK Legislature Party Leader by a meeting of all the MLAs in the party. Tamil Nadu Governor Ch. Vidyasagar Rao accepted the resignation of Chief Minister O. Panneerselvam on 6 February 2017, and instructed him to continue to function as acting Chief Minister "until alternate arrangements are made". The Governor delayed announcing VK Sasikala as the new Chief Minister, waiting for the verdict of the misappropriation case on her. On February 14, 2017, VK Sasikala was convicted and sentenced to 4 years sentence in Bangalore Parapana Jail and gave her 24 hours to surrender. Then the governor rejected her claims to become Chief Minister. VK Sasikala then convened the party's MLA council in her capacity as the General Secretary. There, Mr. Edpappadi K. Palaniasamy was unanimously elected as the new Chief Minister and he was sworn in the next day.

On August 21, 2017, Sasikala was expelled from the AIADMK and removed from her post of General Secretary.

On 14 February 2017, the Supreme Court of India found Sasikala and her co-accused — Ilavarasi (her sister-in-law) and V. N. Sudhakaran (her nephew) — guilty of conspiring, laundering and amassing illicit wealth worth about ₹ 66.44 crore (equivalent to ₹ 292 crore or US$41 million in 2019) in the 1990s in a criminal conspiracy with Jayalalithaa. The three were sentenced to a four-year jail term. This restored in toto her earlier conviction in the case delivered on 27 September 2014, sentencing a four-year jail term to her and her relatives, in addition to imposing a fine of ₹ 10 crore (US$1.4 million) each. The judgment stipulated that she and her accomplices would serve an additional 12 months in prison if they failed to pay the fine.

The Supreme Court refused her plea to surrender after a fortnight and to be allowed to have food from home, so Sasikala and Ilavarasi presented themselves for imprisonment on 15 February 2017.

In a meeting held on 29 December 2016 – the first meeting after Jayalalithaa's death on 5 December 2016 – the AIADMK general council appointed Sasikala as the party's general secretary.

On 19 December 2011, Jayalalithaa expelled Sasikala Natarajan and 13 others including Sasikala's husband M. Natarajan, T. T. V. Dhinakaran, their relatives, and Jayalalithaa's foster son V. N. Sudhakaran from the AIADMK. This act of Jayalalithaa was considered a way to prove that she was not under the influence of Sasikala and her family. The matter was resolved by 31 March 2012, when Sasikala Natarajan was reinstated as a party member after issuing a written apology.

She was arrested along with Jayalalithaa on 7 December 1996 and was remanded to judicial custody for 30 days in connection with the Colour TV scam. During Jayalalithaa's three tenures as Chief Minister, Sasikala was alleged to have laundered huge amounts of wealth amassed by Jayalalitha. On 14 February 2017, a two-bench Supreme Court jury pronounced her guilty and ordered her immediate arrest in a disproportionate-assets case, effectively ending her chief ministerial ambitions.

Vivekanandan Krishnaveni Sasikala, married name Sasikala Natarajan, is an Indian politician and the president of the Amma Makkal Munnetra Kazhagam from Tamil Nadu,She was a friend and close aide of J. Jayalalithaa, the late Chief Minister of Tamil Nadu, who headed AIADMK from 1989 until her death in 2016. After Jayalalithaa's death, the party's general council elected her as the secretary general of AIADMK, She is the aunt of T.T.V. Dhinakaran, general secretary of AMMK.

In the early 1980s, through V. S. Chandralekha, who was then the District Collector of South Arcot, and a friend of M.Natarajan, Sasikala gained acquaintance with Jayalalithaa, who was then the Propaganda Secretary of the Anna Dravida Munnetra Kazhagam. Since Sasikala helped in video coverage of party meetings and distribution of policies of AIADMK through CD's, Sasikala and Jayalalithaa gradually became very close.